Ketoconazole is used in Treatment of superficial and deep mycoses : Infections of the skin, hair and nails by dermatophytes and/or yeasts (dermatomycosis, onychomycosis, perionyxis, pityriasisversicolor, chronic mucocutaneous candidiasis etc.) especially when topical treatment is difficult or not very effective, owing to involvement of large skin surfaces or to lesions affecting deeper dermal layers, nails and hairs ; Yeast infection of the mouth (oral thrush, perleche) and the gastrointestinal tract ; Vaginal candidiasis, especially chronic recurrent cases or cases responding poorly to topcial treatment ; Systemic mycotic infections such as systemic candidiasis, paracoccidioidomycosis, histoplasmosis, coccidioidomycosis etc.
2. Maintenance treatment to prevent recurrence in systemic mycotic infections and in chronic mucocutaneous candidiasis.
3. Prophylactic treatment to prevent mycotic infection in patients with reduced host defenses, e.g., patients with cancer, organ transplant and burns